Vayne excels as a late-game hyper-carry, melting tanky frontlines with her percentage true damage and utilizing stealth for kiting. Consider picking her when high sustained DPS is crucial.
She synergizes well with peel-focused supports like Lulu or Thresh, but struggles if your team lacks wave clear. Her performance in the bottom lane is currently considered subpar by many.
While she can be strong against immobile melee champions in the top lane, her early game is vulnerable. Overall, Vayne is often seen as a frustrating champion to play against, with many players requesting nerfs or a rework.