Vayne has a very weak early lane phase and poor synergy with most supports. Prioritize safe farming under tower, even if you miss some CS.
Endure her weak laning phase; Vayne scales incredibly well into the late game with her powerful W ability. Focus on her late-game carry potential.
While she can be a strong counter-pick in the top lane, her slow wave clear and early weakness can put pressure on your team.
Stats
Q
W
E
R